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Whats Next: Regulatory filing for weight management: by end of 2025 Submission for type 2 diabetes: expected in 2026 Drug discovered by Chugai, licensed by Lilly in 2018 Implication: Orforglipron could become the first once-daily oral GLP-1 therapy with potent glucose-lowering and weight-loss benefits, potentially disrupting the injectable incretin market.

While major weight loss may not occur yet, most patients notice: A reduction in appetite

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Retatrutide, on the other hand, is still in clinical trials, and its mental health impact is not yet fully understood