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For the change in body weight, seven trials were at high risk of bias and one trial had some concerns

First, physicians should be aware that GLP-1 RAs provide a variety of advantages beyond weight loss and glycemic control, especially for T2D patients with established cardiovascular disease, elevated CRP, elevated cardiovascular risk, MASLD/MASH, or chronic kidney disease

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Concerning signs that require medical attention include: Spreading redness larger than a few inches Red streaks Severe or worsening pain Fever or chills Hives away from the site Facial or throat swelling Any breathing difficulty When symptoms worsen rather than improve, document the site with a photo and contact your clinician promptly so they can assess for infection or a true allergic response