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The majority of studies indicate that GLP-1 RAs are associated with an increased risk of gallbladder or biliary tract diseases ( 2 = 3.5%) ( GLP-1 RAs may induce cholecystitis and cholelithiasis through multiple mechanisms, including altering bile composition by increasing cholesterol secretion into bile

Current treatments are limited and often lead to significant side effects, underscoring the need for new, well-tolerated options

"The lack of standardized production and FDA oversight makes it difficult to assess the consistency and potency of oral formulations," explains Dr

For the study, Wong induced systemic inflammation in mice by either injecting them with a bacterial cell wall component or a bacterial slur to induce sepsis, an extensive inflammation throughout the body that leads to organ damage