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The administration of exogenous androgens, such as mesterolone, has been shown to increase the cross-sectional area of oxidative muscle fibers, particularly when combined with endurance exercise (149)

Gene Expression Effects A landmark study by Pickart and Margolina found that GHK-Cu influences a remarkably broad set of genes upregulating genes associated with collagen production, angiogenesis, and skin repair while downregulating genes associated with inflammation and tissue degradation (including certain matrix metalloproteinases that, when overexpressed, can break down existing collagen)

Increased oxidative DNA damage, lipid peroxidation, and reactive oxygen species in cultured orbital fibroblasts from patients with Graves ophthalmopathy: evidence that oxidative stress has a role in this disorder

Pedosphere 25 , 202211 (2015)