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Although the use of first-generation uncouplers (e.g., dinitrophenol, DNP) was limited by significant toxicity, subsequent experimental studies and early clinical observations have highlighted the potential benefits of controlled mitochondrial uncoupling in both metabolic diseases and cancer (Goedeke and Shulman, 2021

Next, logarithmically transformed and autocentered abundances for metabolites and lipids were analyzed by multivariate general linear models to test the frequentist hypothesis that point estimates for metabolites and lipids were significantly different between ME/CFS and SC when corrected for gender, exercise (nonexercise vs

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