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These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics

The microbial metabolites, short-chain fatty acids, regulate colonic T reg cell homeostasis

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[20] Cytochrome isoforms affected by grapefruit components include CYP1A2, CYP2C9, and CYP2D6, [21] [22] [23] [24] [25] but CYP3A4 is the major CYP enzyme in the intestine