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In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)

Fourth, the translation of mechanistic insights from animal or in vitro models remains tentative, as these systems may not recapitulate the complex interplay of metabolic, hormonal, and immune factors in human PCOS