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Of note, there was a statistically significant association after adjustment for other covariates, such as gender, age, HBV genotype, baseline HBV DNA, HBsAg, HBeAg, and ALT levels ( Table 3 )

Therefore, it is recommended that individuals at an elevated risk of bleeding, those taking specific anticoagulants and antiplatelet agents, and those undergoing surgical or other invasive operations should avoid it (Rosenblatt and Mindel, 1997)

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