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Similarly, both the phase III METGastric trial, evaluating the addition of onartuzumab to first-line chemotherapy with mFOLFOX6 (oxaliplatin, 5-fluorouracil and leucovorin) in HER2 -negative, c - MET -positive metastatic gastric or GEJ cancers, and a randomized phase II study, investigating the activity of onartuzumab plus first-line FOLFOX-bevacizumab in CRC, failed to demonstrate significant results [100, 101]

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Due to multiple comparisons (12 metals), only p-values below 0.004 should be considered significant, and p values between 0.05 and 0.004 should be considered marginally significant

Gaetke LM, Chow CK