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We conducted a comprehensive literature search across databases, including PubMed and Web of Science, compiling data from clinical trials, case reports, and basic research studies published up to 2025, with a focus on the efficacy, safety, and mechanism of action of drugs such as liraglutide, semaglutide, and tirzepatide in patients with MC4R deficiency
On the contrary, an excess is starting to be associated with: the proliferation and onset of cancer, hepatic-renal damage, neurodegenerative diseases, as well as heart and cardiovascular diseases
A history of gallstones, gallbladder disease, pancreatitis, rapid weight loss, or a family history of gallstones should be discussed with the prescribing clinician