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In particular, the nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway, is important for ROS scavenging via the antioxidant system

Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers

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This delayed transit contributes to prolonged satiety and reduced hunger signals, which supports weight loss but can also increase gastrointestinal discomfort if dietary choices are not optimized