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See a doctor if: Your lips remain dry despite intensive care for weeks The corners of the mouth are permanently cracked (cheilitis angularis) You additionally suffer from fatigue, paleness, or hair loss (possible nutrient deficiency) The lips scale strongly, itch, or become inflamed (possible allergy or infection) You take medications that cause skin dryness as a side effect (e.g., retinoids, blood pressure medication) Potential Medical Causes Nutrient deficiency : Vitamin B deficiency, iron deficiency, or zinc deficiency often show up on the lips first Sjgren syndrome : This autoimmune disease reduces saliva production and leads to chronically dry lips Contact allergies : Ingredients in toothpaste, lipstick, or care products can trigger allergic reactions Herpes simplex : Blisters on the lips often transition into a phase of extreme dryness Thyroid diseases : An underactive thyroid can manifest through dry, chapped lips A doctor can identify nutrient deficiencies through a blood test and initiate the correct treatment