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Combining them during dose escalation phases could amplify GI symptoms, though this is not a contraindicationjust a reason to space doses and monitor comfort carefully

Animal studies suggest that high concentrations of 1,25(OH)2D are necessary to generate Tregs when supplemented, but this can lead to adverse side effects such as hypercalcemia

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NOX2-ROS, on the other hand, suppresses STAT5 phosphorylation and GATA-3 expression, relieving the Th2 bias against Th1 and indirectly promoting Th1 differentiation