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The recording chamber, with a volume of 500 L, was continuously superfused at a rate of 12 mL/min

Although body mass index (BMI) remains widely used as a diagnostic parameter, current approaches increasingly recognize obesity as a heterogeneous metabolic disorder shaped by adipose tissue dysfunction, circulating metabolites, dietary patterns, host genetics, pharmacological exposure, and gut microbiota composition (Mouawad et al., 2025)

For help choosing between formulations, our semaglutide versus tirzepatide comparison covers the broader landscape of GLP-1 options