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CONFLICT OF INTEREST The authors of this work declare that they have no conflicts of interest

2.9 Gut microbiome alteration There is still much controversy as to what constitutes a healthy microbiome and it is difficult to classify bacteria as either good or bad

F., Arena, J

The isoform of this enzyme (PI3K) is also involved in insulin signaling, and the inhibition of this pathway by either pan-PI3K inhibitors (i.e., copanlisib and duvelisib) or specific PI3K inhibitors (i.e., alpelisib and inavolisib) can lead to hyperglycemia (250)

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