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2018 Jan;147:141-152
A longevity label is not clinical evidence Describing a product as a longevity peptide, telomere peptide or pineal bioregulator does not establish that it changes human ageing, healthspan or survival
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The system gets flooded with NAD+ at levels up to ten times higher than normal, which raises concerns about: Potential mitochondrial dysfunction Possible sirtuin overactivation Disruption of methylation processes [8] NAD+ at very high levels may block poly(ADP-ribose) polymerases (PARPs) and possibly compromise DNA repair mechanisms [8]
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