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First-time anti-obesity medication (AOM) prescribing increased 21.7% from December 2025 to March 2026, with first-time AOM semaglutide prescribing increasing by more than 50%

218 However, the inhibition effect of STF-31 was partially suppressed by nicotinic acid in NAPRT positive cell lines

Future efforts should focus on validating non invasive diagnostic tools, integrating multidisciplinary care models, and improving access to specialized services

Epigenetic profiling further demonstrated an age-associated accumulation of repressive H3K27me3 marks and the formation of bivalent chromatin domains, which limit the expression of regenerative genes and contribute to MuSC dysfunction