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A commenter recommended that CMS monitor ASC feedback during the voluntary reporting period to ensure ASCs do not face widespread technical or operational challenges which would require postponing mandatory implementation

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Subcutaneous administration near the injury site provides both high local concentration and some systemic distribution as the peptide migrates to areas of damage throughout the body

Baseline Testing Standard baseline labs include: Full hormone panel (thyroid, sex hormones, cortisol, IGF-1 as a proxy for growth hormone) Metabolic markers (lipids, glucose, fasting insulin, A1C) Inflammatory markers (CRP, homocysteine) Liver and kidney function Gut-related tests when digestive system symptoms are present Lab testing is crucial before and during peptide therapy to monitor hormone levels and catch any shifts early