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In accordance with the international recommendations, bone formation marker procollagen type I intact N-terminal propeptide (P1NP) and bone resorption marker collagen type I C-telopeptide (CTX) were generated using commercially available chemiluminescence protocols (Immunodiagnostics Systems, The Boldens, United Kingdom), as conducted previously (Wherry et al., 2019)

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MT1 also serves as a tool in inflammation-linked neurobiology research

Aged mice (12 months, roughly equivalent to middle age in humans) administered MOTS-c for four weeks showed improved physical performance, grip strength, and metabolic markers compared to controls