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Our medical team recognizes the potential of GLP-1 medications to help patients achieve sustainable weight loss and improved metabolic health

Peripherally circulating GLP-1 (143) and some GLP-1RAs, such as liraglutide and semaglutide (145), can readily access the CVOs, including the subfornical organ and the area postrema, which express GLP-1R and have close neuroanatomical connections with hypothalamus involved in forage and satiety control

Additionally, presumably due to the high concentration of DPP-4 found on hepatocytes, 4050% of the remaining active GLP-1 is degraded across the liver

10.1016/s0140-6736(64)90011-x 53 MooreB