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Reduced MTHFR activity reduced methionine regeneration reduced SAM production reduced methylation capacity across all SAM-dependent methyltransferase reactions consequences that propagate through epigenetics, neurotransmitter metabolism, creatine synthesis, phosphatidylcholine production, and the broader biochemistry that SAM sustains

Common risks include: Kidney strain or potential damage Skin rashes and allergic reactions Risk of infection from unsterile injections Overdose due to incorrect administration Long-term dependency on injections for maintaining skin tone Since glutathione injections directly affect internal organs, individuals with liver or kidney problems should avoid them