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GLP-1 and GIP are hormones naturally released by the body after meals, aiding in glycemic Trusted Source The Body Weight Reducing Effects of Tirzepatide in People with and without Type 2 Diabetes: a Review on Efficacy and Adverse Effects Thomas Leth Jensen, Brnden A, Karstoft K, Sonne D, Christensen M Go to Source control

Mol Cell Biochem 481 , 28332849 (2026)

The first is endocrine, where GLP-1 enters the bloodstream and reaches the hypothalamus through the area postrema, a region of the brainstem that lacks a complete blood-brain barrier