Black tarry stools, bright red blood, or pale clay-coloured stools with jaundice require urgent medical assessment to exclude serious complications
Although inhibition of the COX-1 enzyme is thought to be the cause of adverse effects, such as gastric ulceration, even COX-2selective drugs have been associated with adverse effects, and safety in sick cats is not well evaluated
Factors such as side effects, high out-of-pocket costs, injection fatigue and stigma around obesity treatment drive troves of patients some studies estimate roughly half or more to stop GLP-1s within a year and risk regaining the weight they lost
The investigators found that compared with metformin, GLP-1 RA therapy was associated with the following: A 26% reduction in all-cause mortality A 13% reduction in hospitalizations Up to a 48% reduction in amputations An approximately 36% reduction in revascularization procedures in obstructed lower extremity arteries Rates of myocardial infarction, stroke, and serious kidney events were similar between the treatment groups
