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NNMT-inhibitor research has shifted from early proof-of-concept work (20142017) to integrated preclinical programmes combining pharmacological NNMT inhibition with exercise-training research protocols (Dimet-Wiley 2024) and with hepatic/metabolic research endpoints (Zhang 2025)

Other contraindications and precautions for GLP-1 agonists include a history of severe allergic reactions to the medication or its components, acute or chronic pancreatitis, gallbladder disease or gallstones, and certain forms of diabetic retinopathy