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Other Ancestral Peoples For other peoples, the consumption of guayusa is also part of their identity, being used mainly as a stimulant and for pain relief, as in the Shuar ethnic group, who drink the infusion for its multiple benefits but do not incorporate it as a daily ritual activity, the Secoya people who use it to treat physical ailments, the Cofn ethnic group who use it extensively in the preparation of various drinks, and the Tsachi community, where it is drunk and the leaves are used in steam baths, for medicinal purposes, to relieve menstrual issues [2,7]

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Knockdown of SLC1A5_var resulted in reduced GSH and increased ROS levels, while overexpression of SLC1A5_var promoted PC cell and tumor growth [36]