To evaluate the impact of Syn constructs on chaperone-mediated refolding, denatured luciferase (40 nM) was incubated with DNAJB1 (1.0 M) and HSPA8 (2.0 M) in the presence of Syn constructs at a molar ratio of 1:2 (HSPA8:Syn)
Exogenous alanine and/or glucose plus kanamycin kills antibiotic-resistant bacteria
The addition of the thiol reductant, dithiothreitol, at the start of phase 2, prevented and reversed the toxicological damage that would otherwise occur, in the absence of any reduction in covalent binding or resynthesis of GSH
Clin Nutr ESPEN 46:510518 Sadlier C, Albrich WC, Neogi U, Lunjani N, Horgan M, OToole PW, OMahony L (2022) Metabolic rewiring and serotonin depletion in patients with postacute sequelae of Covid-19