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In these systems, stimulusresponsive platforms, such as those responsive to pH [447], redox [448], and light [449] have been implemented for controlled drug release

Materials and Methods Cell Line and Cell Treatment INS-1 cells were procured from the National Infrastructure of Cell Line Resource (Beijing, China) and cultured in RPMI-1640 (Invitrogen, Carlsbad, CA, United States) added with L-glutamine, FBS (10%

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019