astrazeneca glp 1 pipeline AstraZeneca to advance in-licensed oral

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Colonic mRNA expression analysis in Glp1r / mice at baseline reveal significant reductions in trefoil factor ( Tff-1 and -2), transforming growth factor ( Tgf-b1 and Tgf-3 ), epidermal growth factor receptor ( Egfr ), keratinocyte growth factor ( Fgf7 ), hepatocyte growth factor ( Hgf ) (epithelial protection and repair), Il6, Il1b (innate immune response), Il12b (inflammation) (Yusta et al., 2015)

CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency