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10.3389/fphar.2022.692828 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Gatti M, Antonazzo IC, Diemberger I, De Ponti F, Raschi E

Rare cases of muscle weakness or cramps

Beyond gastrointestinal effects, the following safety signals and class-relevant cautions warrant attention: Heart rate elevation: Retatrutide's glucagon receptor agonism has been associated with modest increases in resting heart rate in Phase 2 data

Overall psychiatric safety Large analyses have not shown an overall increase in psychiatric adverse events with GLP-1 receptor agonists and some data suggest improvements in emotional eating and restrained eating behaviors