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Similarly, a meta-analysis of six placebo-controlled trials indicated that the worsening of diabetic retinopathy correlated with reductions in average HbA1c rather than with GLP-1 RA treatment [92]

35 Without this stimulus, especially during a calorie deficit potentially exacerbated by GLP-1 effects, the body may be less efficient at utilizing dietary protein for muscle maintenance, leading to greater lean mass loss

Lilly's next-gen Triple G (GLP-1/GIP/glucagon) agonist (Phase 1b, Phase 2): started recruiting for a Phase 3 trial this year approvals are expected by 2026

Tirzepatide can help clarify which path makes the most sense for your goals