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Symptoms can include: chest pain when exercising dizziness fainting for no apparent reason feeling that your heart is pounding, racing, or skipping a beat severe pain, pressure, or tightness in your chest, arm, throat, neck, or jaw shortness of breath nausea and vomiting cold sweat drooping on one side of the face sudden weakness or numbness in one arm slurred speech or trouble speaking Problems with blood circulation in your fingers and toes, such as Raynauds syndrome

Overall, there is evidence that T cells are important in early viral control and infection blockade , thus providing support for the inclusion of T-cell antigens within next-generation vaccines alongside B-cell antigens

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Managing DPN remains challenging due to its complex and poorly understood pathophysiology, varied clinical manifestations, and underdeveloped staging [23,174]