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Vitamin B12 deficiency can arise from various factors, including dietary deficiencies, malabsorption syndromes, or certain medical conditions

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Because the therapeutic potential of supplemental coenzyme Q 10 is limited to its capacity to restore electron transfer in a defective mitochondrial respiratory chain and/or to increase antioxidant defense, patients with secondary coenzyme Q 10 deficiency may fail to respond to supplementation (see Disease Treatment)

doi:10.1016/j.bcp.2017.11.007