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The limited success of targeted medication can be attributed to multiple factors, including cytokine interactions of this complex and convoluted system with immunological redundancy, translatability of animal models to humans, individual responses to therapy, and side effects of these therapeutic agents [1]

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The study found that, after six weeks of treatment, all doses of enclomiphene citrate increased LH levels compared to the testosterone supplementation arm, which reported suppressed LH levels