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Many professional organizations and medical societies recognize approved GLP1 receptor agonist-based obesity medications, including semaglutide and tirzepatide, as highly-effective for treating excess adiposity in adults with obesity or overweight and related complications

The peptide upregulates VEGF (vascular endothelial growth factor) and modulates signaling pathways active during organogenesis, but no studies have directly evaluated teratogenicity or tracked fetal outcomes after in utero exposure

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