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In a Mayo Clinic study presented at an annual meeting of the Endocrine Society in July 2025, researchers found that, over 18 months, 40 postmenopausal women who combined the GLP-1 drug tirzepatide (used in Mounjaro and Zepbound) with hormone therapy lost an average of 17 percent of their body weight

But they are also precisely why a thorough understanding of GHK-Cu contraindications is non-negotiable

Local administration is commonly used because its effects appear strongest close to the target tissue

Understanding variants in genes like GIPR and GLP1R reveals whether you're genetically predisposed to dramatic cholesterol improvements or modest gains, allowing PlexusDx providers to personalize your protocol and set realistic targets