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doi: 10.1007/s00125-022-05787-2 9 MollHFreyEGerberPGeidlBKaufmannMBraunJet al

Treated mice displayed myofibers nearly twice as large in cross-sectional area and demonstrated higher contractile strength, with reports of up to 70% greater force compared to untreated groups

Although most macromolecules in the blood are physically prevented from entering the brain due to the presence of the blood-brain barrier and tight junctions, specific and non-specific transcellular mechanisms transport various macromolecules and complexes across the blood-brain barrier