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But for people who hate needles, these medications hold a glaring, obvious drawback: They require taking a weekly shot

RISING STARS: endocrine regulation of metabolic homeostasis via the intestine and gut microbiome

It's a type of hormone that cells in your intestines release after you eat

Use with Medications Known to Cause Hypoglycemia Sitagliptin As is typical with other antihyperglycemic agents used in combination with a sulfonylurea, when sitagliptin was used in combination with metformin and a sulfonylurea, a medication known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo in combination with metformin and a sulfonylurea [see Adverse Reactions]