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In a recent study aimed at investigating IGF-IR and GHR physiology in patients with MASLD, Osganian et al

The transport of carnitine across epithelial cells of the intestine, kidney, and placenta, as well as into the liver, brain, heart, muscle, epididymis, and airway tissues, is shown

Koba S, Yokota Y, Hirano T, et al

Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism