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To dissect the upstream regulatory mechanism of miR-29b-3p under Gln deprivation conditions, we integrated transcriptome data (GSE148016) from both Gln+ and Gln- groups, and performed cross-analysis with the predicted upstream transcription factors of miR-29b-3p, ultimately identifying five candidate transcription factors

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Finally, the pleiotropy-original sin hypothesis postulates that cell death is an immanent and inevitable process associated with the formation of metabolic by-products in cells like reactive oxygen species (ROS) and cell death machinery components-encoding genes were not initially related to cell death processes and performed pro-survival functions