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In addition, NADPH generation via glutamine metabolism in cancer cells supports redox homeostasis by maintaining the cytosolic NADPH pool used to restore oxidized glutathione 29 (Fig

Likewise, nicotinic acid reduces vascular inflammation through inhibition of NLRP3 inflammasome signaling pathway (Al-Kuraishy et al

The reaction was immediately stopped with 0.1 M glycine on a rotor for 5 min at room temperature

Our study has important implications for our understanding of enzymatically active and inactive glutaredoxins and could be useful for the design and optimization of artificial glutaredoxins, glutaredoxin-coupled fluorescent redox sensors and transition-state inhibitors