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Specifically, we found that GSSG elevation suppressed the phosphorylation/activation of IKK-, a proximal kinase in the NF-B signaling pathway that phosphorylates IB-, leading to its proteasomal degradation and subsequent NF-B activation

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As various factors such as genetic inheritance, environmental toxins, oxidative stress, and mitochondrial dysfunction are probably involved in the pathogenesis of the disease, it is very challenging to understand the pathogenesis of Parkinson's disease