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Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy

Acknowledgments The writing of the manuscript was assisted by ChatGPT (OpenAI, California, US) and Grammarly (Superhuman Platform Inc., California, US) for language support

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IL-8 has been shown to act on mucin post-translationally through increasing the levels of RNA-binding proteins to improve stability of the mucin transcripts ( MUC5B and MUC5AC gene expression in primary tracheal epithelial cells (Chen et al., 2003), and IL-17A caused an increase of MUC5AC in primary human bronchial epithelial cells through the NF-B enhancer of MUC5AC gene transcription (Fujisawa et al., 2011