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Through coordinated regulation of bioenergetics, oxidative defense, and mitophagy, these pathways define a shared downstream mitochondrial inflammatory final common pathway through which diverse antidepressant interventions exert their therapeutic effects in MDD

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10.1093/jac/dkaa093 J Antimicrob Chemother

Once activated, these microglia release neurotoxic substances that further damage neuronal synapses and disrupt the synthesis of vital neurotransmitters like acetylcholine, dopamine, and serotonin