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QD community oral or SC MOTS-c Daily SC, often 5 days on / 2 off AOD-9604 Daily SC Attribute Max studied dose SLU-PP-332 50 mg/kg BID (mouse, 28 days) MOTS-c 5-15 mg/kg (mouse) AOD-9604 1-5 mg/day in human Phase 2 Attribute Peak efficacy signal SLU-PP-332 ~25-30% fat-mass reduction in DIO mice over 28 days MOTS-c Improved insulin sensitivity in aged mice AOD-9604 Modest fat-loss signal in human Phase 2

The British Medicines Act that stated that medicines that are injected are available only on prescription was passed in a world that was very different from today

The cost to the Medicare enrollee depends on the tier at which the plan defines Ozempic

Administer ZEPBOUND once weekly at any time of day, with or without meals