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Manuel Jurado, principal at consulting firm the Dedham Group, told Healthcare Brew that coverage could lead to overall cost savings in the future, as GLP-1s have been shown to reduce the odds of developing chronic illnesses like diabetes and cardiovascular disease

Other peptides that the body makes include insulin, substance P, neuropeptide Y, ghrelin, CCK, leptin, leuteinizing hormone, thyroid-stimulating hormone, and more

Verdict at a Glance Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss

Long-Term Accumulation Weekly Peak: The highest concentration reached shortly after an individual dose (13 days)