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Funding This study was funded by the Ministerio de Sanidad, Poltica Social e Igualdad , Spain (EC10-115, EC10-116, EC10-117, EC10-119, EC10-122) and by CAIBER - Spanish Clinical Research Network

This dose-response consideration informs why research protocols rarely exceed the documented dose ranges

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If levels are very low, initial weekly visits can help build a foundation, then you may shift to every two to four weeks for maintenance