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Skin and wrinkle studies Reviews summarizing topical GHK-Cu studies have described improvements in measured skin density, thickness, laxity, and appearance of fine lines over 12-week study windows, along with a well-documented topical safety profile (Topically applied GHK as an anti-wrinkle peptide, 2024)

At the same time, the frequency of symptoms was evaluated using a 5-point Likert scale with 0: none of the time, 1: a little of the time, 2: about half the time, 3: most of the time, and 4: all of the time