CYP7A1 is the rate-limiting enzyme in converting cholesterol to bile acids, and LXRs, which function as cholesterol sensors, increase Cyp7a1 expression in response to acute cholesterol intake in mice [2,33]
By contrast, cystine, cysteine, and -glutamylcysteine, intermediate metabolites of the glutathione synthesis pathway (Figure 1E), were decreased in the kidneys with TLS
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(The most common side effects of GLP-1s are gastrointestinal.) We should always keep evaluating their safety, but we have a good understanding of what this class of medicine does, and it has a pretty favorable risk-benefit ratio, Drucker says
