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It has long been known that alcohol consumption induces a preference for carbohydrate (specifically sugars) intake and that sugar intake induces a higher likelihood for alcohol consumption

MMA is a genetically heterogeneous disorder, with the majority (~60%) of cases caused by complete ( mut 0 ) or partial ( mut ) deficiency of the enzyme methylmalonyl-CoA mutase (MMUT) and the remainder due to errors in the synthesis or transport of 5-deoxyadenosylcobalamin, a vitamin B 12 derivative and essential cofactor of the reaction (1, 2)

And it certainly is very distressing for a lot of patients of mine

Body-weight fluctuations and outcomes in coronary disease