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Weight Loss: Average weight loss in the LEAD trials was 2 kg to 3.24 kg, with the majority of the reduction noted in the first 4 months of therapy, but tending to be sustained throughout the remaining period of the studies

To help maintain stability and peptide integrity, repeated freeze-thaw cycles should be avoided

Wang L, Wang A, Guo H, Zhang Z, Wang S, Pei T, Liu Z, Yang D, Liu Y, Ruan C (2021) Neuroprotective effects of long-term metformin preconditioning on rats with ischemic brain injuries